She was born to Ravi Varma and Uma Varma and belongs to the Nedumpuram Palace clan in Tiruvalla, Kerala. She hails from Thrissur, had never thought of becoming an actress although her aunt Urmila Unni had already been recognized as an accomplished actress, active in both Cinema and Teleserials in Malayalam. She had also learned dancing but had no plans to become a professional dancer either. When she was studying at Sree Kerala Varma College, Thrissur, she got the offer to do the female lead role in Veendum Chila Veettukaaryangal.

Samyuktha did so well that her first movie Veendum Chila Veetukaryangal hit the theatres (in 1999) and the audience didn't ever feel that the girl doing the lead role was miscast. But hit-makerJoshi's Vazhunnor, released in 1999 itself, proved all speculations wrong. In 1999 Samyuktha Varma being cast in her third film, Chandranudikkunna Dikkil by Lal Jose, in which she was one of the two heroines, the other being debutante Kavya Madhavan. And also in the cast was Biju Menon, co-starring with whom in two of her later films, Samyuktha was to give scintillating performances. The year 2000 was not very fruitful to Samyuktha. Her second film opposite Jayaram, Nadanpennum Naattupramaaniyum of director Rajasenan, though the film appealed very much to Rajasenan's fans, it didn't do much good business at the box office.
And then came a film that could be perhaps one of Samyuktha's most ambitious ventures. She was cast for the first time opposite National award-winning superstar Mohanlal in hit-maker Fazil's home production Life is Beautiful. The film grossed average. Director Mohan's Angane Oru Avadhikaalaththu, in which Samyuktha was cast opposite Sreenivasan, offered her as well etched out the role, which she did to perfection.
Then Samyuktha Verma stunned the audience with real scintillating and sensitive performances in three of her films. The first was Mazha, noted director Lenin Rajendran's film based on a short story by noted writer Madhavikutty. Samyuktha won accolades as Bhadra, a young girl caught between two worlds-one full of romantic dreams, poetry and music, and the other replete with bitter and harsh realities. Lost between these two worlds, Bhadra was indeed a well etched out role for Samyuktha and she did full justice to her role.
Then came Kamal's Madhuranombarakaattu, in which she was again cast opposite Biju Menon as Priyamvada, who finds that life for her is an unending war against fate which has nothing but sorrows in store for her. This again was a really sensitive role. Along with Madhuranombarakaattu, Swayamvarapanthal was released, directed by national award-winning filmmaker Harikumar. As Priya opposite Jayaram, Samyuktha lived in the role of an insane girl with a haunting past.

Though Samyuktha Varma did really wonderful work of her different roles, commercial success went on eluding her films. Her films in 2000, from Naadanpennum Naattupramaaniyum toSwayamvarapanthal, all were flops. But the year ended on a promising note for this young actress, as far as the commercial aspect is concerned. Rafi-Mecartin's Thenkasi Pattanam, in which she is one of the three heroines, did well and was a super hit. Starring opposite Suresh Gopi, Samyuktha dons the role of Meenakshi, a character that is more of a lighter vein compared to her earlier characters. Her next movie Meghasandesham didn't do well in the box office. Rajasenan's horror movie with Suresh Gopi, newcomer Rajshri Nair and Abhirami too in the cast was a flop.

Her most noted characters are-that of Bhadra in Mazha and that of Priyamvada in Madhuranombarakaattu.